Within minutes of stimulation of the cell, β subunit of

I-κB kinase becomes activated by phosphorylation

TLS Online TPP Program

#Id: 8649

#XL - T Zoology

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8650

#XL - T Zoology

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition

TLS Online TPP Program

#Id: 8651

#XL - T Zoology

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

TLS Online TPP Program

#Id: 8652

#XL - T Zoology

TLS Online TPP Program

#Id: 8653

#XL - T Zoology

Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.

TLS Online TPP Program

#Id: 8654

#XL - T Zoology

Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase