Integrins typically exhibit low affinities for their ligands, with dissociation constants (Kd) between 10−6 and 10−7 mol/L.

TLS Online TPP Program

#Id: 8528

#XL - Q Biochemistry

Polyglutamylation has a key role in the beating of cilia and flagella

TLS Online TPP Program

#Id: 8527

#XL - Q Biochemistry

Kinesin-1 associates preferentially with detyrosylated and acetylated microtubules.

TLS Online TPP Program

#Id: 8526

#XL - Q Biochemistry

Polyglutamylation and polyglycylation are likely mutually exclusive, so they would not normally occur at the same time & both can enhance microtubule stability,

TLS Online TPP Program

#Id: 8525

#XL - Q Biochemistry

Detyrosylated microtubules are more stable, because they are more resistant to depolymerization by kinesin-13 and related proteins.

TLS Online TPP Program

#Id: 8524

#XL - Q Biochemistry

Detyrosylation 

tyrosine can be removed by a carboxypeptidase, where it sequentially removes the C-terminal tyrosines from α-tubulin subunits. 

TLS Online TPP Program

#Id: 8523

#XL - Q Biochemistry