Ligand binding triggers a conformational change in the JAKs & they phosphorylate each other on a critical tyrosine in the activation loop which greatly enhances kinase activity

TLS Online TPP Program

#Id: 9778

#XL - R Botany

Effector‐triggered immunity is a second level of induced defense and stronger than PTI and culminates in the hypersensitive response (HR).

TLS Online TPP Program

#Id: 9779

#XL - R Botany

R proteins trigger ETI contains LRR motif which have parallel β‐sheets

TLS Online TPP Program

#Id: 9780

#XL - R Botany

LRR motif also found in the extracellular domain of several P/MAMP

TLS Online TPP Program

#Id: 9781

#XL - R Botany

R gene products are also called as NBS–LRR

TLS Online TPP Program

#Id: 9782

#XL - R Botany

According to the guard hypothesis, R gene products “guard” cellular proteins, which are called guardees or decoys

TLS Online TPP Program

#Id: 9783

#XL - R Botany

Guard hypothesis says that the Interaction between the guardees and the pathogen effectors is required for successful infection by the pathogen.