Three signals are required for activation of a naïve T cell

TLS Online TPP Program

#Id: 10385

#XL - Q Biochemistry

Cross-presentation

TLS Online TPP Program

#Id: 10386

#XL - Q Biochemistry

Presentation of nonpeptide antigens derived from pathogens involves the nonclassical class I–like CD1 molecule

TLS Online TPP Program

#Id: 10387

#XL - Q Biochemistry

Class I presentation requires internal synthesis of virus protein, as shown by the requirement that the target cell be infected by live virus, and by the inhibition of class I presentation observed when protein synthesis was blocked by the inhibitor emetine.

TLS Online TPP Program

#Id: 10388

#XL - Q Biochemistry

Class II presentation can occur with either live or replication-incompetent virus; protein synthesis inhibitors had no effect, indicating that new protein synthesis is not a necessary condition of class II presentation. 

TLS Online TPP Program

#Id: 10389

#XL - Q Biochemistry

Class II, but not class I, presentation is inhibited by treatment of the cells with an agent that blocks endocytic processing within the cell (chloroquine).

TLS Online TPP Program

#Id: 10286

#XL - Q Biochemistry

T cells initiate the adaptive immune response by interacting MHC on antigen-presenting cells that have been exposed to pathogens.