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TLS Online TPP Program

#Id: 8607

Cdk1 
=Cdc2 (vertebrates and fission yeast)
= Cdc28  (budding yeast)

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TLS Online TPP Program

#Id: 8607

#XL - T Zoology

Cdk1 
=Cdc2 (vertebrates and fission yeast)
= Cdc28  (budding yeast)
TLS Online TPP Program

#Id: 9944

#XL - T Zoology

Malaria (Parasitic)

Sporozoites enter the bloodstream by mosquito.

The sporozoites migrate to the liver, where they multiply, transforming liver hepatocytes into giant multinucleate schizonts, which release thousands of merozoites into the bloodstream. 
TLS Online TPP Program

#Id: 9945

#XL - T Zoology

The merozoites infect red blood cells, which eventually rupture, releasing more merozoites. 
TLS Online TPP Program

#Id: 9946

#XL - T Zoology

Eventually some of the merozoites differentiate into male and female gametocytes, which are ingested by a mosquito and differentiate into gametes in the mosquito’s gut. 
TLS Online TPP Program

#Id: 9947

#XL - T Zoology

The gametes fuse to form a zygote that differentiates to the sporozoite stage within the salivary gland of the mosquito.
TLS Online TPP Program

#Id: 9948

#XL - T Zoology

Leishmaniasis

Leishmania is a flagellated protozoan that lives in the phagosomes of macrophages and is transmitted by sand flies.
TLS Online TPP Program

#Id: 9949

#XL - T Zoology

Resistance to leishmaniasis correlates well with the production of IFN-ϒ and the development of a TH1 response.
Strains of mice that are naturally resistant to Leishmania develop a TH1 response and produce IFN-ϒ upon infection.