The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 8986

#XL - T Zoology

Calculation of Allelic Frequencies

TLS Online TPP Program

#Id: 8987

#XL - T Zoology

Allele frequency when genotype frequency is given

TLS Online TPP Program

#Id: 8988

#XL - T Zoology

TLS Online TPP Program

#Id: 8989

#XL - T Zoology

Allele frequency when genotype frequency is given

TLS Online TPP Program

#Id: 8990

#XL - T Zoology

Adaptive introgression

When the incorporation of a foreign variant leads to an increase of the fitness of the recipient pool.

TLS Online TPP Program

#Id: 8991

#XL - T Zoology

Incomplete lineage sorting (hemiplasy)

If you make a phylogenetic tree of how the alleles are related to each other, it does not mirror how the species split apart.