The idea behind CARs was to engineer the T-cell receptor to trigger activation of ZAP70 in response to the presence of a tumor-specific antigen rather than the MHC peptide complex. 

TLS Online TPP Program

#Id: 9210

#XL - T Zoology

Genetic bottleneck

Genetic drift arises is through a genetic bottleneck, which develops when a population undergoes a drastic reduction in size

TLS Online TPP Program

#Id: 9705

#XL - T Zoology

The receptors for yeast α and a mating factors are coupled to the same trimeric G protein.

TLS Online TPP Program

#Id: 7049

#XL - T Zoology

He proposed that the embryonic development of an individual organism (its ontogeny) followed the same path as the evolutionary history of its species (its phylogeny).

TLS Online TPP Program

#Id: 10382

#XL - Q Biochemistry

Expression of class II molecules by B cells is down-regulated by IFN-¥.

TLS Online TPP Program

#Id: 9727

#XL - R Botany

The active principle in foxglove (Digitalis sp.) is cardinolide digitoxin, a cardiac glycoside that inhibits ATPase activity and can increase myocardial contraction.