B cells migrate to the lymphoid follicles. They are directed there by chemokine interactions between CXCL13, which is secreted by follicular dendritic cells (FDCs).

TLS Online TPP Program

#Id: 10051

#XL - T Zoology

The force accompanying the movement of Delta into the signaling cell stretches the Notch protein on the responding cell and allowing access by ADAM 10, which cleaves the Notch extracellular domain

TLS Online TPP Program

#Id: 10052

#XL - T Zoology

Second cleavage of Notch occurs within membrane-spanning region & catalyzed by γ-secretase

TLS Online TPP Program

#Id: 10053

#XL - T Zoology

γ-secretase complex contains 

Presenilin 1 (actual protease), aph-1, pen-2, & nicastrin

TLS Online TPP Program

#Id: 10054

#XL - T Zoology

Cleavage by the γ-secretase complex releases the Notch cytosolic segment, which translocates to the nucleus, interacts with a single DNA-binding transcription factor, CSL.

TLS Online TPP Program

#Id: 10055

#XL - T Zoology

Growth factors and EGFs are synthesized as TM proteins, regulated cleavage of the precursor by members of the ADAM protease releases the active molecule into the extracellular space.

TLS Online TPP Program

#Id: 10056

#XL - T Zoology

Cell-adhesion molecules (CAMs) mediate direct cell-cell adhesions.