Corticosteroids and prostaglandins can also decrease expression of class II MHC molecules.

TLS Online TPP Program

#Id: 10006

#XL - T Zoology

Hedgehog protein with autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion.

TLS Online TPP Program

#Id: 10007

#XL - T Zoology

TLS Online TPP Program

#Id: 10008

#XL - T Zoology

The freed C-terminal is not involved in signaling and is often degraded, whereas the N-terminal becomes the active Hedgehog protein intended for secretion

TLS Online TPP Program

#Id: 10009

#XL - T Zoology

Secretion requires the addition of cholesterol and palmitic acid to the Hedgehog protein

TLS Online TPP Program

#Id: 10010

#XL - T Zoology

Two membrane proteins, 

Smoothened (Smo) 

Patched (Ptc)

TLS Online TPP Program

#Id: 10011

#XL - T Zoology

Smo has seven TM α helices, is a member of the GPCR superfamily, and is related in sequence to the Fz.