GRB2 SH2 domain binds to a specific phosphotyrosine residue in the cytosolic domain of an activated RTK.

 

TLS Online TPP Program

#Id: 7966

#XL - Q Biochemistry

Binding of BiP to the luminal domain of monomeric Ire1 prevents formation of the Ire1 dimer.

TLS Online TPP Program

#Id: 7965

#XL - Q Biochemistry

Unassembled or misfolded proteins in the ER are often transported back to the cytosol, where they are degraded in the ubiquitin-proteasome pathway

TLS Online TPP Program

#Id: 7964

#XL - Q Biochemistry

Emphysema caused by a point mutation in -antitrypsin, which is normally secreted by hepatocytes and macrophages.

TLS Online TPP Program

#Id: 7963

#XL - Q Biochemistry

A hereditary form of emphysema illustrates the detrimental effects that can result from misfolding of proteins in the ER.

TLS Online TPP Program

#Id: 7962

#XL - Q Biochemistry

Hac1 activates transcription of genes encoding several protein-folding catalysts.

TLS Online TPP Program

#Id: 7961

#XL - Q Biochemistry

Quantity of free BiP in the ER lumen determines the relative proportions of monomeric and dimeric Ire1.