MEK, a dual-specificity protein kinase

TLS Online TPP Program

#Id: 9090

#XL - T Zoology

This results in continuous activation of the AC of intestinal epithelial cells, chronically active PKA which phosphorylates the CFTR Cl- channel and a Na-H exchanger in the intestinal epithelial cells. 

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The resultant efflux of NaCl triggers massive water loss through the intestine as cells respond to the ensuing osmotic imbalance causes severe dehydration and electrolyte loss.

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#Id: 9092

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Pertussis toxin, produced by Bordetella pertussis, catalyzes ADP-ribosylation of the  subunit of Gαi, preventing GDP-GTP exchange and blocking inhibition of adenylyl cyclase.

TLS Online TPP Program

#Id: 9093

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Ligand binding to GPCRs that activate Gαq, leading to activation of phospholipase C

TLS Online TPP Program

#Id: 9094

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Phospholipase C cleaves a phospholipid known as PI(4,5) P2, generating two second messengers: 

diffusible IP3 and membrane-bound DAG

TLS Online TPP Program

#Id: 9095

#XL - T Zoology