Acetyl-CoA and NADH are potent allosteric inhibitors of the enzyme. 

TLS Online TPP Program

#Id: 8151

#XL - Q Biochemistry

Sec12

acts as a GEF factor for Sar1

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#XL - Q Biochemistry

After the vesicle coat is complete, the Sec23 coat subunit promotes GTP hydrolysis causes disassembly of the coat.

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#XL - Q Biochemistry

A second function of small GTPases in vesicle formation is in the pinching off of a completed vesicle from the parent membrane

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#XL - Q Biochemistry

Sar1 GTPase drives the pinching off of COPII vesicles

ARF GTPase drives the pinching off of COPIvesicles

Dynamin GTPase drives the pinching off of clathrin-coated vesicles

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#XL - Q Biochemistry

Two different kinds of sorting signals:

Membrane cargo proteins carry cytoplasmic sorting signals

Soluble cargo proteins carry luminal sorting signals

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#XL - Q Biochemistry