Two different kinds of sorting signals:

Membrane cargo proteins carry cytoplasmic sorting signals

Soluble cargo proteins carry luminal sorting signals

TLS Online TPP Program

#Id: 9609

#XL - T Zoology

Phosphorylation leads to a conformational change in the activation loop that unblocks kinase active site by reducing the Kd for ATP or the substrate to be phosphorylated.

TLS Online TPP Program

#Id: 8621

#XL - T Zoology

The Cip/Kip family members bind to cyclin-bound CDKs and block the activity of cyclin D-, E-, A-, and B-containing complexes.

TLS Online TPP Program

#Id: 8914

#XL - T Zoology

Following securin degradation and a decrease in mitotic CDK activity, separase cleaves the Scc1 subunit, breaking the cohesin circles.

TLS Online TPP Program

#Id: 8869

#XL - T Zoology

Yeast cells with a defective wee1+ gene activate mitotic CDKs prematurely and premature entry into mitosis (smaller than normal cells

TLS Online TPP Program

#Id: 8029

#XL - Q Biochemistry