Eukaryotic cells have two isozymes of aconitase

• The mitochondrial isozyme (convert citrate to isocitrate in the citric acid cycle)

• The cytosolic isozyme 

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Antagonists of Wnt:

Secreted frizzled-related protein (Sfrp)

Wnt inhibitory factor (Wif)

Dickkopf (Dkk) family

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Non-canonical Wnt signaling is initiated by the 

Wnt5a type (Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, and Wnt11).

 

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Wnt ligands are recognized by Frizzled/retinoic acid-related orphan receptor (ROR)/receptor tyrosine kinase (RYK) receptor complexes

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Frizzled paired with Ror and Ror receptor complex phosphorylates Disheveled

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Disheveled stimulate activation of the small GTPases Rho and Rac, leading to cytoskeletal rearrangements and cell motility.