TLS Online TPP Program

#Id: 9339

#XL - T Zoology

TGF-β is synthesized with a, 

250-residue N-terminal prodomain

∼110-residue C-terminal TGF-β domain

TLS Online TPP Program

#Id: 9340

#XL - T Zoology

N-terminal prodomain is required for proper folding and dimerization of the C-terminal TGF-β domain.

TLS Online TPP Program

#Id: 9341

#XL - T Zoology

TGF-β latency

In the Golgi prodomain is proteolytically cleaved from the mature growth factor but remains noncovalently attached even after secretion.

TLS Online TPP Program

#Id: 9342

#XL - T Zoology

Prodomain prevents the latent TGF-β 

from binding to a cell-surface receptor.

TLS Online TPP Program

#Id: 9343

#XL - T Zoology

Prodomain forms disulfide linkages that localize the latent TGF-β to the surface of the secreting cell (GARP), to a nearby cell, or to the extracellular matrix (LTBP).

TLS Online TPP Program

#Id: 9345

#XL - T Zoology

TGF-β activation

By cytoskeletal force transmitted by integrins