In healthy mitochondria, PINK1 resides in the mitochondrial matrix.

In damaged or dysfunctional mitochondria, PINK1 resides on the outer mitochondrial membrane, where it recruits cytosolic Parkin.

#Id: 7908

#XL - Q Biochemistry

In healthy mitochondria, PINK1 resides in the mitochondrial matrix.

In damaged or dysfunctional mitochondria, PINK1 resides on the outer mitochondrial membrane, where it recruits cytosolic Parkin.

#Id: 7949

#XL - Q Biochemistry

3 glucose (Glc)

9 mannose (Man)

2 N-acetylglucosamine (GlcNAc)

Glc3Man9(GlcNAc)2

#Id: 7948

#XL - Q Biochemistry

#Id: 7947

#XL - Q Biochemistry

#Id: 7946

#XL - Q Biochemistry

O-linked oligosaccharides

Carbohydrate chains in glycoproteins attached to the

hydroxyl group (-OH) in serine and threonine residues

#Id: 7945

#XL - Q Biochemistry

Glycoproteins

Proteins with attached carbohydrates

#Id: 7944

#XL - Q Biochemistry

Membrane and soluble secretory proteins synthesized on the rough ER undergo four principal modifications before they reach their final destinations: 

(1) Glycosylation in the ER and Golgi complex

(2) Formation of disulfide bonds in the ER

(3) Proper folding of polypeptide chains and assembly of multisubunit proteins in the ER

(4) Specific proteolytic cleavages in the ER, Golgi complex, and secretory vesicles