Signal sequence

ER targeting sequence, located at the N-terminus of the protein

TLS Online TPP Program

#Id: 8852

#XL - R Botany

Geminin contains a destruction box at its N-terminus that is recognized by APC/Ccdh1, causing it to be ubiquitinylated in late anaphase and degraded by proteasomes.

TLS Online TPP Program

#Id: 10092

#XL - T Zoology

Inside-out signaling

intracellular signaling pathways can, via adapter proteins, modify the ability of integrins to bind

to their extracellular ligands

TLS Online TPP Program

#Id: 8162

#XL - Q Biochemistry

For selective export of certain membrane proteins from the ER contain a di-acidic sorting signal (Asp-X-Glu, or DXE), which binds to the Sec24 subunit of the COPII

TLS Online TPP Program

#Id: 10324

#XL - Q Biochemistry

PD-1 has a structure similar to CTLA-4 and when activated negatively regulates T-cell function by inducing apoptosis of activated T cells. 

TLS Online TPP Program

#Id: 7920

#XL - Q Biochemistry