A system to unambiguously describe the configurations of molecules with more than one asymmetric center was devised in 1956 by Robert Cahn, Christopher Ingold, and Vladimir Prelog. In the Cahn–Ingold– Prelog or RS system

TLS Online TPP Program

#Id: 7907

#XL - Q Biochemistry

Parkinson’s disease is caused by mutations in two gene encoding proteins that can mediate mitophagy:

PINK1 (a kinase)

Parkin (E3 ubiquitin ligase)

TLS Online TPP Program

#Id: 7906

#XL - Q Biochemistry

When the environment of a cell has inadequate oxygen, enzymatic modification of proteins on the outer mitochondrial membrane induces mitophagy.

TLS Online TPP Program

#Id: 7905

#XL - Q Biochemistry

Mitophagy provides Mitochondrial Quality Control

TLS Online TPP Program

#Id: 7904

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 7903

#XL - Q Biochemistry

Mitochondrial fusion and fission are mediated by a set of GTPase enzymes:

Mitochondrial fusion -MFN1/2 & OPA1

Mitochondrial fission- DRP1

TLS Online TPP Program

#Id: 7902

#XL - Q Biochemistry

Single mutation in the TΨCG loop of the mitochondrial lysine tRNA

“Ragged-red” muscle fibers & uncontrolled jerky movements