A system to unambiguously describe the configurations of molecules with more than one asymmetric center was devised in 1956 by Robert Cahn, Christopher Ingold, and Vladimir Prelog. In the Cahn–Ingold– Prelog or RS system

TLS Online TPP Program

#Id: 8343

#XL - Q Biochemistry

formin family members have two adjacent domains:

FH1- rich in proline, landing site for profilin–ATP–G-actin

FH2 - form a dimer and nucleate filament assembly

TLS Online TPP Program

#Id: 8342

#XL - Q Biochemistry

TLS Online TPP Program

#Id: 8341

#XL - Q Biochemistry

Two major classes of actin-nucleating proteins:

1. Formins nucleate the assembly of unbranched filaments 

2. Arp2/3 complex nucleates the assembly of branched actin networks

TLS Online TPP Program

#Id: 8340

#XL - Q Biochemistry

Gelsolin, is regulated by Ca+2 ion concentration and sever actin filaments.

TLS Online TPP Program

#Id: 8339

#XL - Q Biochemistry

Filament capping proteins:

CapZ blocks (+)end Tropomodulin blocks (-)end

TLS Online TPP Program

#Id: 8338

#XL - Q Biochemistry

Profilin can bind proteins with sequences rich in proline residues at the same time it is bound to actin.