Isoleucine and Threonine have two chiral carbons so exists in multiple RS configuration.

TLS Online TPP Program

#Id: 8940

#XL - T Zoology

Knl1 eliminating checkpoint protein binding sites at kinetochores. p31comet disassembles the MCC, allowing APC/Ccdc20 to degrade mitotic cyclins and securin to trigger anaphase.

TLS Online TPP Program

#Id: 8941

#XL - T Zoology

Spindle position checkpoint pathway ensures that the nucleus is accurately partitioned between two daughter cells

TLS Online TPP Program

#Id: 8942

#XL - T Zoology

In S. cerevisiae, during interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. 

TLS Online TPP Program

#Id: 8943

#XL - T Zoology

Inactive Tem1-GDP associates with the spindle pole body nearest to the bud as soon as the mitotic spindle forms

TLS Online TPP Program

#Id: 8944

#XL - T Zoology

If chromosome segregation occurs properly, extension of the spindle microtubules inserts the daughter SPB into the bud, causing Tem1 to be activated by an unknown mechanism.

TLS Online TPP Program

#Id: 8945

#XL - T Zoology

Tem1-GTP activates a protein kinase cascade, which promotes the release of active Cdc14 from the nucleolus and exit from mitosis.