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TLS Online TPP Program

#Id: 8159

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER

#XL - Q Biochemistry #Golgi Apparatus #Part B Pointers
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TLS Online TPP Program

#Id: 8159

#XL - Q Biochemistry

KDEL receptor, located mainly in the cis-Golgi network and in both COPII and COPI vesicles, binds proteins bearing the KDEL sorting signal and returns them to the ER
TLS Online TPP Program

#Id: 7956

#XL - Q Biochemistry

A branched oligosaccharide containing 

3 glucose (Glc)

9 mannose (Man)

2 N-acetylglucosamine (GlcNAc)

Glc3Man9(GlcNAc)2
TLS Online TPP Program

#Id: 7955

#XL - Q Biochemistry

Only asparagine residues in the tripeptide sequences Asn-X-Ser and Asn-X-Thr (where X is any amino acid except proline) are substrates for oligosaccharyl transferase.
TLS Online TPP Program

#Id: 7954

#XL - Q Biochemistry

The precursor oligosaccharide is transferred from a
dolichol lipid anchor to the asparagine as an intact unit in a reaction catalyzed by a transmembrane oligosaccharyl transferase enzyme complex.
TLS Online TPP Program

#Id: 7953

#XL - Q Biochemistry

Tunicamycin

blocks the first enzyme in this pathway, inhibits the synthesis of all N-linked oligosaccharides in cells.
TLS Online TPP Program

#Id: 7952

#XL - Q Biochemistry

Two N- acetylglucosamine (GlcNAc) and five mannose residues are added one at a time to a dolichol phosphate on the cytosolic face of the ER membrane
TLS Online TPP Program

#Id: 7951

#XL - Q Biochemistry

First sugar residue is attached to dolichol by a high-energy pyrophosphate linkage & the other sugars are added by glycosidic bonds