Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 8167

#XL - Q Biochemistry

Most common CFTR mutation is a ΔF508 -

Prevents normal transport of CFTR to the plasma membrane by blocking its packaging into COPII vesicles budding from the ER. 

Change the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24.

TLS Online TPP Program

#Id: 9914

#XL - T Zoology

Tools against infectious diseases

TLS Online TPP Program

#Id: 9915

#XL - T Zoology

Intracellular infections are the most difficult for the immune system to detect and eradicate; these can be divided into membrane-bound and cytosolic, with differing key immune response mediators

TLS Online TPP Program

#Id: 9916

#XL - T Zoology

Viral Infections

Virus enters a cell via a cell-surface receptor for which it has affinity and preempts cell biosynthetic machinery to replicate all components of itself, including its genome.

This genome replication step is often error prone, generating numerous mutations.

TLS Online TPP Program

#Id: 9917

#XL - T Zoology

Influenza virus binds to sialic acid residues

Rhinovirus binds to intercellular adhesion molecules (ICAMs)

Epstein Barr virus (EBV) binds to type 2 complement receptors on B cells

TLS Online TPP Program

#Id: 9918

#XL - T Zoology

Innate response elements commonly engaged by encounter with viral PAMPs, such as secretion of type I interferons, inflammasome and NK-cell activation, as well as IL-12 production.

TLS Online TPP Program

#Id: 9919

#XL - T Zoology

Mechanisms of humoral and cell-mediated immune responses