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TLS Online TPP Program

#Id: 8347

To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)

#XL - Q Biochemistry #MICROFILAMENTS #Part B Pointers
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TLS Online TPP Program

#Id: 8339

#XL - Q Biochemistry

Filament capping proteins:

CapZ blocks (+)end Tropomodulin blocks (-)end
TLS Online TPP Program

#Id: 8338

#XL - Q Biochemistry

Profilin can bind proteins with sequences rich in proline residues at the same time it is bound to actin.
TLS Online TPP Program

#Id: 8337

#XL - Q Biochemistry

Profilin – G-actin nucleotide exchange (ADP to ATP) 
Cofilin – F-actin disassembly
Thymosin B-4 – G-actin monomer sequestering
TLS Online TPP Program

#Id: 8336

#XL - Q Biochemistry

Actin filament treadmilling is accelerated by:

Profilin and Cofilin
TLS Online TPP Program

#Id: 8335

#XL - Q Biochemistry
TLS Online TPP Program

#Id: 8334

#XL - Q Biochemistry

Phalloidin 
isolated from Amanita phalloides, binds at the interface between subunits in F-actin, locking adjacent subunits together and preventing depolymerization.