To nucleate the assembly of branched actin filaments, Arp2/3 needs to be activated by a nucleation promoting factor (NPF)

TLS Online TPP Program

#Id: 8623

#XL - R Botany

SCF and APC/C are multisubunit ubiquitin-protein ligases that belong to the RING finger family of ubiquitin-protein ligases.

TLS Online TPP Program

#Id: 8625

#XL - R Botany

Human SCF complexes contain: 

Three core components - Cul1 subunit, RBX1, Skp1 

and a substrate-targeting F-box protein

TLS Online TPP Program

#Id: 8626

#XL - R Botany

RBX1 is a RING finger–containing protein that binds the E2 ubiquitin-conjugating enzyme.

TLS Online TPP Program

#Id: 8627

#XL - R Botany

phosphoserine/threonine-binding F-box protein is Skp2, which uses a series of leucine-rich repeats to bind to target proteins only when they are phosphorylated.

TLS Online TPP Program

#Id: 8628

#XL - R Botany

APC/C consists of 14 core subunits in metazoans and 13 core subunits in yeast.

TLS Online TPP Program

#Id: 8629

#XL - R Botany

APC/C works with substrate-targeting factors called Cdc20 and Cdh1