If the concentration of the enzyme or substrate is increased, the rate of the reaction will be increased as well. 

If the temperature of the enzymes surrounding environment is increased, then the rate of the reaction will also be increased. 

If the substrate concentration is increased then the rate of the reaction will increase. 

If an inhibitor is added then the rate of the reaction will be decreased significantly

TLS Online TPP Program

#Id: 8614

#XL - T Zoology

Two inhibitory phosphorylations on CDK play a critical role in controlling CDK activity:

Y15

T14

TLS Online TPP Program

#Id: 8615

#XL - T Zoology

Y15 & T14 are situated in the G-loop of the CDK, containing the consensus sequence GEGT14Y15GVV

TLS Online TPP Program

#Id: 8616

#XL - T Zoology

Phosphorylation of T14 and Y15 in this G-loop

introduces negative charge that electrostatically interferes with the binding of ATP in the catalytic pocket.

TLS Online TPP Program

#Id: 8617

#XL - T Zoology

Wee1 kinase Inhibits CDKs in all organisms

TLS Online TPP Program

#Id: 8618

#XL - T Zoology

Cdc25 phosphatase Activates CDKs in fission yeast

TLS Online TPP Program

#Id: 8619

#XL - T Zoology

INK4s

bind to CDK4 and CDK6 monomers, blocking their interaction with cyclin D