TLS Online TPP Program

#Id: 8647

#XL - T Zoology

TLS Online TPP Program

#Id: 9703

#XL - T Zoology

An a haploid cell secretes the a mating factor and has GPCRs for the α factor on its cell surface; an α cell secretes the α factor and has GPCRs for the a factor.

TLS Online TPP Program

#Id: 9704

#XL - T Zoology

Activation of the MAP kinase pathway by either the a or the α GPCRs induces transcription of genes that inhibit progression of the cell cycle

TLS Online TPP Program

#Id: 9705

#XL - T Zoology

The receptors for yeast α and a mating factors are coupled to the same trimeric G protein.

TLS Online TPP Program

#Id: 9706

#XL - T Zoology

Ligand binding to either of the two yeast pheromone GPCRs triggers the exchange of GTP for GDP on the Gα subunit and dissociation of Gα∙GTP from the Gβγ complex.

TLS Online TPP Program

#Id: 9707

#XL - T Zoology

Ligand binding and dissociation of the G protein subunits, the membrane-tethered Gβγ subunit binds the Ste5.

TLS Online TPP Program

#Id: 9708

#XL - T Zoology

Ste5 acts as a scaffold for assembling other components in the cascade Ste11, Ste7, and Fus3.