The cytosolic isozyme has two distinct functions. It catalyzes the conversion of citrate to isocitrate, providing the substrate for a cytosolic isocitrate dehydrogenase that generates NADPH as reducing power for fatty acid synthesis and other anabolic processes in the cytosol. It also has a role in cellular iron homeostasis.

TLS Online TPP Program

#Id: 8881

#XL - T Zoology

Plk1 is critical for formation of the mitotic spindle as well as for chromosome segregation.

TLS Online TPP Program

#Id: 8882

#XL - T Zoology

The Aurora kinase family members Aurora A and Aurora B play key roles in mitotic spindle formation and in ensuring that chromosomes attach correctly to the mitotic spindle so that they are segregated accurately during mitosis.

TLS Online TPP Program

#Id: 8883

#XL - T Zoology

Once mitotic CDKs are activated at the end of G2 , they phosphorylate specific serine residues in all 3 nuclear lamins.

TLS Online TPP Program

#Id: 8884

#XL - T Zoology

This phosphorylation, together with phosphorylation of lamin B by protein kinase C, causes depolymerization of the lamin intermediate filaments.

TLS Online TPP Program

#Id: 8885

#XL - T Zoology

TLS Online TPP Program

#Id: 8886

#XL - T Zoology