Nurturing Life Sciences
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#Id: 7908
#XL - Q Biochemistry
In healthy mitochondria, PINK1 resides in the mitochondrial matrix.
In damaged or dysfunctional mitochondria, PINK1 resides on the outer mitochondrial membrane, where it recruits cytosolic Parkin.
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Parkinson’s disease is caused by mutations in two gene encoding proteins that can mediate mitophagy:
PINK1 (a kinase)
Parkin (E3 ubiquitin ligase)
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#Id: 7905
Mitophagy provides Mitochondrial Quality Control
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#Id: 7903
Mitochondrial fusion and fission are mediated by a set of GTPase enzymes:
Mitochondrial fusion -MFN1/2 & OPA1
Mitochondrial fission- DRP1