The entire process of mitotic CDKs activation and entry into mitosis involves two positive feedback loops and coordination between events at the centrosome, in the cytoplasm, and in the nucleus.

TLS Online TPP Program

#Id: 1330

#XL - T Zoology

Phospholipase C cleaves PI(4,5)P2, generating two second messengers:  IP3 and DAG

TLS Online TPP Program

#Id: 9892

#XL - T Zoology

Pattern recognition

Families of PRRs (TLRs, CLRs, RLRs, and NLRs) recognize a wide variety of PAMP (and DAMP) ligands.

TLS Online TPP Program

#Id: 8900

#XL - T Zoology

The Aurora protein kinase family members Aurora A and Aurora B and their associated regulatory factors sense kinetochores that are not under tension and sever these microtubule attachments

TLS Online TPP Program

#Id: 1825

#XL - T Zoology

TLS Online TPP Program

#Id: 8928

#XL - T Zoology

ATM and ATR, activate a triad of related protein kinases: Chk1, Chk2, and MK2