TLS Online TPP Program

#Id: 10077

#XL - T Zoology

An integrin molecule is composed of two noncovalently associated transmembrane glycoprotein subunits called α and β.

TLS Online TPP Program

#Id: 10078

#XL - T Zoology

TLS Online TPP Program

#Id: 10079

#XL - T Zoology

Integrins function as transmembrane linkers (integrators) between the extracellular matrix and the actin cytoskeleton.

TLS Online TPP Program

#Id: 10080

#XL - T Zoology

Integrins bind extracellular matrix (ECM) glycoproteins, 

1. Laminins  

2. Collagens 

3. Fibronectin

4. Vitronectin

TLS Online TPP Program

#Id: 10081

#XL - T Zoology

Fibronectin binds to integrin through an RGD motif.

TLS Online TPP Program

#Id: 10082

#XL - T Zoology

The binding of integrins to their ligands depends on extracellular divalent cations(Ca+2 & Mg+2)