A1 associates with ARF6, a small G protein in host cells which are accessible only when ARF6 is in its active (GTP-bound) form. 

TLS Online TPP Program

#Id: 9711

#XL - T Zoology

GTP-bound Cdc42, binds to and activates the Ste20 kinase.

TLS Online TPP Program

#Id: 9712

#XL - T Zoology

Ste20 serves as a MAPKKK kinase.

TLS Online TPP Program

#Id: 9713

#XL - T Zoology

Ste20 phosphorylates and activates Ste11, a serine/threonine kinase

TLS Online TPP Program

#Id: 9714

#XL - T Zoology

Ste11 analogous to Raf and other mammalian MEK kinase (MEKK) proteins.

TLS Online TPP Program

#Id: 9715

#XL - T Zoology

Activated Ste11 then phosphorylates Ste7, a dual-specificity MEK.

TLS Online TPP Program

#Id: 9716

#XL - T Zoology

Ste7, phosphorylates and activates Fus3,  a serine/threonine kinase