A1 associates with ARF6, a small G protein in host cells which are accessible only when ARF6 is in its active (GTP-bound) form. 

TLS Online TPP Program

#Id: 8703

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TLS Online TPP Program

#Id: 8704

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TLS Online TPP Program

#Id: 8705

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The cytosolic isozyme has two distinct functions. It catalyzes the conversion of citrate to isocitrate, providing the substrate for a cytosolic isocitrate dehydrogenase that generates NADPH as reducing power for fatty acid synthesis and other anabolic processes in the cytosol. It also has a role in cellular iron homeostasis.

TLS Online TPP Program

#Id: 8706

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TLS Online TPP Program

#Id: 8707

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KDC shows Divergent evolution, in which the genes for an enzyme with one substrate specificity give rise, during evolution, to closely related enzymes with different substrate specificities but the same enzymatic mechanism.

TLS Online TPP Program

#Id: 8708

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This reaction is catalyzed by nucleoside diphosphate kinase