The PRD domain of phyB serve as an NLS. 

Conversion of Pr to Pfr by red light expose the functional NLS of the PRD domain of phyB, facilitating phyB’s import into the nucleus.

TLS Online TPP Program

#Id: 8630

#XL - T Zoology

TLS Online TPP Program

#Id: 8631

#XL - T Zoology

APC/C core is organized into three modules: 

1. a scaffold module 

2. a catalytic module

3. a substrate recognition module

TLS Online TPP Program

#Id: 8632

#XL - T Zoology

Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif, the destruction box or D-box, has the consensus sequence

RXXLX[D/E]ΦΦΦXN[N/S]

TLS Online TPP Program

#Id: 8633

#XL - T Zoology

Mutating or deleting the destruction box in mitotic cyclins prevented their ubiquitination and blocked cells from exiting mitosis.

TLS Online TPP Program

#Id: 8634

#XL - T Zoology

At the metaphase to anaphase transition, APC/C bound to Cdc20 targets cyclins A /B and securin for degradation.

TLS Online TPP Program

#Id: 8635

#XL - T Zoology

During late anaphase, telophase and G1, APC/C bound to Cdh1 targets B type cyclins and geminin for degradation.