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Genetic drift 
Genetic drift is an evolutionary force, in which allelic frequency change over generation Just by chance (sampling error). 
The deviations from the expected ratios are random, the direction of change is unpredictable.

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G1/S phase CDKs phosphorylate Cdh1 at the 
G1-S phase transition

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S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

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Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.

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Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase

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