3 or 4 cGMP molecules must bind to each channel in order to open it; because of this cooperative allosteric interaction, channel opening is very sensitive to small changes in cGMP levels.

TLS Online TPP Program

#Id: 10084

#XL - T Zoology

Several integrin α subunits contain, I-domain, which can mediate binding of integrins to various collagens in the ECM.

TLS Online TPP Program

#Id: 10085

#XL - T Zoology

I-domains also recognize CAMs on other cells, 

ICAMs, VCAMs and participate in cell-cell adhesion.

TLS Online TPP Program

#Id: 10086

#XL - T Zoology

The non-I-domain α subunits recognize RGD motif.

TLS Online TPP Program

#Id: 10087

#XL - T Zoology

TGF-β1 and TGF-β3 contain RGD motif that binds to integrins.

TLS Online TPP Program

#Id: 10088

#XL - T Zoology

Integrins typically exhibit low affinities for their ligands, with dissociation constants (Kd) between 10−6 and 10−7 mol/L.

TLS Online TPP Program

#Id: 10089

#XL - T Zoology

Integrins are involved in biological activities, includes: 

Extravasation

Cell-to-cell adhesion

Cell migration

Receptors for certain viruses

Angiogenesis

Apoptosis