Smad4 was originally called DPC (deleted in pancreatic cancer)

TLS Online TPP Program

#Id: 9689

#XL - T Zoology

Binding of insulin to its receptor triggers activation of a protease that catalyzes a site-specific endoproteolytic cleavage of TUG

TLS Online TPP Program

#Id: 9690

#XL - T Zoology

Released N-terminal TUG fragment bind to the kinesin, initiates the microtubule-based movement of the GSVs to the plasma membrane.

TLS Online TPP Program

#Id: 9691

#XL - T Zoology

Movement of the GSVs to the plasma membrane is regulated by two monomeric GTP-binding proteins -RalA and Rab10

TLS Online TPP Program

#Id: 9692

#XL - T Zoology

Insulin receptor activates the PI-3 kinase/PKB pathway

TLS Online TPP Program

#Id: 9693

#XL - T Zoology

Active PKB, phosphorylates

and inhibits the GTP→GDP hydrolysis activity of two GAP

proteins - AS160 and RGC

TLS Online TPP Program

#Id: 9694

#XL - T Zoology

Phosphorylation causes the binding of AS160 to the 

14-3-3 protein that sequesters it in the cytosol away from its target Rab proteins