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Where, though, do these hereditary variations come from?
This was the great gap in Darwin’s theory, and he never filled it. The problem was serious because, according to the prevailing belief in blending inheritance, variation should decrease, not increase.

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During exit from mitosis and G1, 
Cdh1 is de-phosphorylated and APC/Ccdh1 is active.

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During S phase and mitosis, 
Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

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G1/S phase CDKs phosphorylate Cdh1 at the 
G1-S phase transition

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S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

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