Extracellular region of a classical cadherin contains five copies of the cadherin domain separated by flexible hinge regions

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In staphylococcal food poisoning and toxic shock syndrome, exotoxins produced by the pathogens function as superantigens, which can activate all T cells. 

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Extracellular Bacteria

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Intracellular bacterial

Intracellular bacterial infections tend to induce a cell-mediated immune response, specifically DTH. 

In this response, cytokines secreted by CD4+ T cells are important—most notably IFN-ϒ, which activates macrophages.

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Host immune responses and bacterial evasion mechanisms

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Tuberculosis

Tuberculosis, caused by Mycobacterium tuberculosis.

Pulmonary infection usually results from inhalation of small droplets of respiratory secretions containing a few bacilli.

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The inhaled bacilli are ingested by alveolar macrophages in the lung and inhibiting formation of phagolysosomes

CD4+ T cells are activated within 2 to 6 weeks after infection.