The inhaled bacilli are ingested by alveolar macrophages in the lung and inhibiting formation of phagolysosomes

CD4+ T cells are activated within 2 to 6 weeks after infection.

TLS Online TPP Program

#Id: 10045

#XL - T Zoology

In Notch/Delta pathway, 

Notch is receptor protein, on a neighboring responding cell

TLS Online TPP Program

#Id: 10046

#XL - T Zoology

In the absence of Delta, 

TM subunit of Notch on the surface of a responding cell is non-covalently associated with its extracellular subunit; extracellular domain is folded

TLS Online TPP Program

#Id: 10047

#XL - T Zoology

Folded extracellular domain cannot

be cleaved by the cell-surface ADAM 10.

TLS Online TPP Program

#Id: 10048

#XL - T Zoology

ADAM 10 is a matrix metalloprotease, a member

of a class of metal-containing enzymes that cleave the

extracellular segments of target proteins.

TLS Online TPP Program

#Id: 10049

#XL - T Zoology

ADAM is an abbreviation for a disintegrin and

Metalloprotease (disintegrin is a conserved protein domain that binds integrins and disrupts cell-matrix interactions)

TLS Online TPP Program

#Id: 10050

#XL - T Zoology

Binding of Notch to Delta 

is followed by endocytosis of Delta by the signaling cell