Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)

TLS Online TPP Program

#Id: 8849

#XL - T Zoology

Phosphorylation of MCM helicase activators by G1/S phase CDKs and S phase CDKs, prevents reloading of MCM helicases (ensuring that replication from each origin occurs only once during each cell cycle)

TLS Online TPP Program

#Id: 8883

#XL - T Zoology

Once mitotic CDKs are activated at the end of G2 , they phosphorylate specific serine residues in all 3 nuclear lamins.

TLS Online TPP Program

#Id: 8884

#XL - T Zoology

This phosphorylation, together with phosphorylation of lamin B by protein kinase C, causes depolymerization of the lamin intermediate filaments.

TLS Online TPP Program

#Id: 8885

#XL - T Zoology

TLS Online TPP Program

#Id: 8886

#XL - T Zoology

TLS Online TPP Program

#Id: 8887

#XL - T Zoology

The mitotic CDKs phosphorylate specific nucleoporins, which causes nuclear pore complexes to dissociate during prophase. 

TLS Online TPP Program

#Id: 8888

#XL - T Zoology

A key function of mitotic CDKs, together with other protein kinases and ubiquitin-protein ligases, is to induce the formation of the mitotic spindle, also known as the mitotic apparatus.