RasD or RasONC  Replacement of the normal glycine 12 with any other amino acid (except proline) “locks” Ras in the active GTP-bound state.

TLS Online TPP Program

#Id: 9450

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Receptor hetero-dimerization or hetero-oligomerization 

Other cytokines (interleukins and interferons) bind simultaneously to two or more different cytokine receptors

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#Id: 9451

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The extracellular domain of cytokine receptors are constructed of two subdomains, each contains seven conserved β strands folded together

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#Id: 9452

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In cytokine receptors, 

the receptor and kinase are separate polypeptides, encoded by different genes, yet are bound tightly together.

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#Id: 9454

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In cytokine receptors, the tightly bound kinase is known as a JAK kinase.

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#Id: 9455

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Cytokine receptors are stably associated with one or two of the four known JAKs:

JAK1, JAK2, JAK3, and Tyk2

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#Id: 9457

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Each members of JAK family of kinases contains:

An N-terminal domain that binds to the receptor

A C-terminal kinase domain 

A middle pseudokinase domain