In the absence of insulin, the extracellular domain adopts a symmetric inverted U-shaped conformation. 

TLS Online TPP Program

#Id: 8393

#XL - Q Biochemistry

Phosphorylation of MLC 

unfolds the myosin II, active and can assemble into bipolar filaments for contraction

TLS Online TPP Program

#Id: 8392

#XL - Q Biochemistry

The CaM*-Ca2+ complex binds and activates MLC kinase, phosphorylates the myosin LC. 

TLS Online TPP Program

#Id: 8391

#XL - Q Biochemistry

When the Ca2+ level rises, Ca2+ binds CaM.

TLS Online TPP Program

#Id: 8373

#XL - Q Biochemistry

In vertebrate smooth muscle, phosphorylation of the myosin regulatory light chain activates contraction in Ca2+ dependent manner.

TLS Online TPP Program

#Id: 8372

#XL - Q Biochemistry

Thick-filament regulation

Myosin-dependent mechanism regulate contraction in smooth muscle and non-muscle cells.

TLS Online TPP Program

#Id: 8371

#XL - Q Biochemistry

In the presence of ATP,  myosin head releases from the actin filament.