In the absence of insulin, the extracellular domain adopts a symmetric inverted U-shaped conformation. 

TLS Online TPP Program

#Id: 8938

#XL - T Zoology

The Mad1-Mad2 complex bound to a kinetochore adopts the active closed form (Mad2-C) and has the ability to convert inactive open Mad2 (Mad2-O) in the cytoplasm into active closed Mad2 is able to inhibit APC/Ccdc²⁰

TLS Online TPP Program

#Id: 8939

#XL - T Zoology

checkpoint factors Bub1-Bub3, BubR1 and Mad2-C Together, these proteins form the mitotic checkpoint complex

TLS Online TPP Program

#Id: 8940

#XL - T Zoology

Knl1 eliminating checkpoint protein binding sites at kinetochores. p31comet disassembles the MCC, allowing APC/Ccdc20 to degrade mitotic cyclins and securin to trigger anaphase.

TLS Online TPP Program

#Id: 8941

#XL - T Zoology

Spindle position checkpoint pathway ensures that the nucleus is accurately partitioned between two daughter cells

TLS Online TPP Program

#Id: 8942

#XL - T Zoology

In S. cerevisiae, during interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. 

TLS Online TPP Program

#Id: 8943

#XL - T Zoology

Inactive Tem1-GDP associates with the spindle pole body nearest to the bud as soon as the mitotic spindle forms