Innate response elements commonly engaged by encounter with viral PAMPs, such as secretion of type I interferons, inflammasome and NK-cell activation, as well as IL-12 production.

TLS Online TPP Program

#Id: 10082

#XL - T Zoology

The binding of integrins to their ligands depends on extracellular divalent cations(Ca+2 & Mg+2)

TLS Online TPP Program

#Id: 10083

#XL - T Zoology

The α subunit of each integrin is the primary determinant of its extracellular ligand specificity

TLS Online TPP Program

#Id: 10084

#XL - T Zoology

Several integrin α subunits contain, I-domain, which can mediate binding of integrins to various collagens in the ECM.

TLS Online TPP Program

#Id: 10085

#XL - T Zoology

I-domains also recognize CAMs on other cells, 

ICAMs, VCAMs and participate in cell-cell adhesion.

TLS Online TPP Program

#Id: 10086

#XL - T Zoology

The non-I-domain α subunits recognize RGD motif.

TLS Online TPP Program

#Id: 10087

#XL - T Zoology

TGF-β1 and TGF-β3 contain RGD motif that binds to integrins.