Wnt signal transduction pathways classify into:

1. Canonical wnt pathway (β-catenin dependent)

2. Noncanonical wnt pathways (β-catenin independent)

TLS Online TPP Program

#Id: 9089

#XL - T Zoology

ADP-ribosylation blocks the GTPase activity of Gαs and renders Gαs permanently active. 

TLS Online TPP Program

#Id: 8756

#XL - T Zoology

Protein stability is the net balance of forces, which determine whether a protein will be in its native folded conformation or a denatured state.

TLS Online TPP Program

#Id: 8751

#XL - T Zoology

The protein p27 is intrinsically disordered. It wraps around and inhibits the action of several enzymes called protein kinases that facilitate cell division. 

TLS Online TPP Program

#Id: 9934

#XL - T Zoology

Cell wall endotoxins of some gram-negative bacteria activate macrophages, resulting in release of high levels of IL-1 and TNF-α, which can cause septic shock.

TLS Online TPP Program

#Id: 8632

#XL - R Botany

Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif, the destruction box or D-box, has the consensus sequence

RXXLX[D/E]ΦΦΦXN[N/S]