NodA is an N-acyltransferase that catalyzes the addition of a fatty acyl chain.

NodB is a chitin-oligosaccharide deacetylase that removes the acetyl group from the terminal nonreducing sugar.

NodC is a chitin-oligosaccharide synthase that links N-acetyl-D-glucosamine monomers.

TLS Online TPP Program

#Id: 9276

#XL - Q Biochemistry

NodA is an N-acyltransferase that catalyzes the addition of a fatty acyl chain.

NodB is a chitin-oligosaccharide deacetylase that removes the acetyl group from the terminal nonreducing sugar.

NodC is a chitin-oligosaccharide synthase that links N-acetyl-D-glucosamine monomers.

TLS Online TPP Program

#Id: 9276

#XL - S Microbiology

NodA is an N-acyltransferase that catalyzes the addition of a fatty acyl chain.

NodB is a chitin-oligosaccharide deacetylase that removes the acetyl group from the terminal nonreducing sugar.

NodC is a chitin-oligosaccharide synthase that links N-acetyl-D-glucosamine monomers.

TLS Online TPP Program

#Id: 10050

#XL - T Zoology

Binding of Notch to Delta 

is followed by endocytosis of Delta by the signaling cell

TLS Online TPP Program

#Id: 10051

#XL - T Zoology

The force accompanying the movement of Delta into the signaling cell stretches the Notch protein on the responding cell and allowing access by ADAM 10, which cleaves the Notch extracellular domain

TLS Online TPP Program

#Id: 10052

#XL - T Zoology

Second cleavage of Notch occurs within membrane-spanning region & catalyzed by γ-secretase

TLS Online TPP Program

#Id: 10053

#XL - T Zoology

γ-secretase complex contains 

Presenilin 1 (actual protease), aph-1, pen-2, & nicastrin

TLS Online TPP Program

#Id: 10054

#XL - T Zoology

Cleavage by the γ-secretase complex releases the Notch cytosolic segment, which translocates to the nucleus, interacts with a single DNA-binding transcription factor, CSL.

TLS Online TPP Program

#Id: 10055

#XL - T Zoology

Growth factors and EGFs are synthesized as TM proteins, regulated cleavage of the precursor by members of the ADAM protease releases the active molecule into the extracellular space.