Rho GTPases are the “master builders” of the cell because they can activate an array of kinases and cytoskeletal binding proteins that remodel cytoskeletal elements to alter cell shape and movement

TLS Online TPP Program

#Id: 8649

#XL - T Zoology

During S phase and mitosis, 

Cdh1 is phosphorylated, Cdh1 dissociates from APC/C, and APC/C becomes inactive.

TLS Online TPP Program

#Id: 8650

#XL - T Zoology

G1/S phase CDKs phosphorylate Cdh1 at the 

G1-S phase transition

TLS Online TPP Program

#Id: 8651

#XL - T Zoology

S phase cyclin-CDK accumulates in late G1 , they are immediately inactivated by binding of a CKI called Sic1

TLS Online TPP Program

#Id: 8652

#XL - T Zoology

TLS Online TPP Program

#Id: 8653

#XL - T Zoology

Degradation of Sic1 is induced by its phosphorylation by G1/S phase CDKs.

TLS Online TPP Program

#Id: 8654

#XL - T Zoology

Sic1 inhibitor is degraded following its ubiquitinylation by the SCF ubiquitin-protein ligase