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TLS Online TPP Program

#Question id: 13161

Which of the following mechanism depends on the activation of heterotrimeric G proteins?

#Unit 4. Cell Communication and Cell Signaling
  1. During actin filament formation, the inactive formin is activated when its Rho-binding domain (RBD) binds to membrane-bound active Rho-GTP, resulting in exposure of the formin’s FH2 domain, which can then nucleate the assembly of a new actin filament.
  2. Rod cells sense light with the aid of a light-sensitive rhodopsin which is coupled to transducin. On absorption of a photon, the retinal moiety of rhodopsin is immediately converted from the cis isomeric form to the all-trans isomeric form, causing a conformational change that allows rhodopsin to bind the α subunit of transducin.
  3. Ras proteins are “switch” proteins and not directly linked to cell-surface receptors. Ras activation is accelerated by a guanine nucleotide exchange factor (GEF), which binds to the Ras∙GDP complex, causing dissociation of the bound GDP.
  4. During the regulation of microfilament organization, Cdc42 act as molecular switches, inactive in the GDP-bound state and active in the GTP-bound state.
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TLS Online TPP Program

#Question id: 5367

#Unit 8. Inheritance Biology

Following pedigree showing X link recessive disorder. Which of the following confirm a carrier female in a family?
TLS Online TPP Program

#Question id: 5366

#Unit 8. Inheritance Biology

From the following select the possible mode of inheritance and the probability that the child in generation III will show the trait.
TLS Online TPP Program

#Question id: 5365

#Unit 8. Inheritance Biology

The following pedigree shows the inheritance of a common phenotype controlled by an autosomal recessive allele. The probability of carriers in the population is 1/3. What is the probability that a child from parents III-3 and III-4 will show the phenotype?
TLS Online TPP Program

#Question id: 5364

#Unit 8. Inheritance Biology

The inheritance of a given disorder is recorded in families shown below: Based on the above limited information, which one of the following inheritance patterns of disorder was not shown in the family?
TLS Online TPP Program

#Question id: 5362

#Unit 8. Inheritance Biology

From the following select the possible mode of inheritance and the probability that the daughter in generation III will show the trait.
TLS Online TPP Program

#Question id: 5361

#Unit 8. Inheritance Biology

The pedigree shows the inheritance of a RFLP marker through three generations in a single family. A total of 8 alleles (numbered to the left of the blots) are present in the family. The RFLPs of each member of the family are placed directly below his (squares) or her (circles) symbol and RFLP numbers. In Above pedigree, which of the following are not children of second generation parent?