Changes in DNA methylation, as well as changes in the activity of histone-modifying enzymes or chromatin-remodeling complexes, are major drivers of tumorigenesis,

a. Hypermethylation of CpG dinucleotides of TSG gene causes cancer.

b. Hypomethylation of CpG dinucleotides of proto-oncogenes causes cancer.

c. SWI/SNF plays a role in repressing the expression of E2F genes.

d. Gain of SWI/SNF function, just like loss of Rb function.

Which of the statements are INCORRECT;

#Question id: 850

#Unit 1. Molecules and their Interaction Relevant to Biology

The experimental inverse of protein structure prediction, has provided insights into protein folding and stability. Protein design attempts to construct an amino acid sequence that will form a structure such as a sandwich of β sheets or a bundle of α helices;

#Question id: 851

#Unit 1. Molecules and their Interaction Relevant to Biology

Methods is the Rosetta program, formulated by David Baker. To satisfy the program’s computational needs, a volunteer network of ∼100,000 computers, known as Rosetta@home, provides the 500,000 or so hours of processing time required to generate a structure;

#Question id: 852

#Unit 1. Molecules and their Interaction Relevant to Biology

.________ enzyme revealed the relation between the amino acid sequence of a protein and its conformation.

#Question id: 853

#Unit 1. Molecules and their Interaction Relevant to Biology

In the presence of a large excess of _______ the disulfides (cystines) are fully converted into sulfhydryls (cysteines).

#Question id: 856

#Unit 1. Molecules and their Interaction Relevant to Biology

Protein folding is not a completely random, trial-and-error process, This problem was first pointed out by

#Question id: 23908

#Unit 1. Molecules and their Interaction Relevant to Biology