The transformation of a normal cell to a cancer cell is accompanied  by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;

Gene	Primary tumor	Proposed function
i) APC	Colorectal	Binds β ‐catenin acting as transcription factor
ii) BRCA1	Breast	DNA repair
iii) MSH2, MLH1	Melanoma, pancreatic	p16: Cdk inhibitor ARF: stabilizes p53
iv) E‐Cadherin	Breast, colon	Cell adhesion molecule
v) INK4a	Colorectal	Mismatch repair
vi) NF1	Neurofibromas	Activates GTPase of Ras

Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions;

#Question id: 10974

#Unit 7. System Physiology – Animal

A 63-year-old woman returned to work following a vacation in New Zealand. Several days after returning home, she awoke with swelling and pain in her right leg and her leg was blue. She went immediately to the emergency room where an examination showed an extensive deep vein thrombosis involving the femoral and iliac veins on the right side. Following resolution of the clot, this patient will require which treatment in the future?

#Question id: 7315

#Unit 5. Developmental Biology

Following pathway represents apoptosis in drosophila. Identify the proteins A-D sequentially.

#Question id: 9612

#Unit 9. Diversity of Life Forms

The best classification system is that which most closely

#Question id: 1264

#Unit 4. Cell Communication and Cell Signaling

 Desmosomes

#Question id: 3629

#Unit 8. Inheritance Biology

Complementation test for four different mutant phenotype 1, 2 , 3 and  4 were allowed and detect phenotype given table

Pair of mutant                                         phenotype

1 & 4                                                         wild                             

1 & 3                                                         wild

2 & 3                                                         wild  

2 & 4                                                         mutant

What are number of citron that four mutant were belong