The transformation of a normal cell to a cancer cell is accompanied  by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;

Gene	Primary tumor	Proposed function
i) APC	Colorectal	Binds β-catenin acting as transcription factor
ii) BRCA1	Breast	DNA repair
iii) MSH2, MLH1	Melanoma, pancreatic	p16: Cdk inhibitor ARF: stabilizes p53
iv) E-Cadherin	Breast, colon	Cell adhesion molecule
v) INK4a	Colorectal	Mismatch repair
vi) NF1	Neurofibromas	Activates GTPase of Ras

Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions;

#Question id: 5249

#Unit 8. Inheritance Biology

What is the best explanation for why Bernard Davis didn't observe generalized transduction in his U tube experiments?

#Question id: 5250

#Unit 8. Inheritance Biology

A researcher would like to map the location of galE and trpA genes in a new species of bacterium that appears to be closely related to E. coli. He decides to use cotransduction, and generatesnappropriate donor and recipient strains. He is disappointed when cotransduction is not seen in his experiement. What is the most reasonable explanation for this situation?

#Question id: 5251

#Unit 8. Inheritance Biology

What do transduction, transformation, and conjugation have in common?

#Question id: 5253

#Unit 8. Inheritance Biology

In a hypothetical situation, the genes for sex pilus construction and for tetracycline resistance are located together on the same plasmid within a particular bacterium. If this bacterium readily performs conjugation involving a copy of this plasmid, then the resultshould be

#Question id: 5255

#Unit 8. Inheritance Biology

Which of the following is a structure that permits conjugation to occur?

#Question id: 5256

#Unit 8. Inheritance Biology

If the experimental population of E. coli lacks an F factor or F plasmid, and if bacteriophage are excluded from the bacterial cultures, then which of these is a means by which beneficial mutations might be transmitted horizontally to other E. coli cells?