Integrins are involved in biological activities, includes: 

Extravasation

Cell-to-cell adhesion

Cell migration

Receptors for certain viruses

Angiogenesis

Apoptosis

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#Id: 3801

#Unit 5. Developmental Biology

Cell Aggregation & Differentiation is common to all Dictyostelids.

It consists of an interconnected programme of cell movement and cell differentiation.

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#Id: 3802

#Unit 5. Developmental Biology

During growth, unicellular D. discoideum monitor their cell density relative to that of their bacterial food source by secreting a glycoprotein called prestarvation factor at a constant rate.

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#Id: 3803

#Unit 5. Developmental Biology

When the ratio of PSF relative to that of bacteria exceeds a certain threshold, cells stop proliferating and initiate the expression of genes that are required for their aggregation.

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#Id: 3804

#Unit 5. Developmental Biology

Early on during aggregation, gene expression requires the activity of cAMP-dependent protein kinase.

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#Id: 3805

#Unit 5. Developmental Biology

High PSF to food ratio is upregulate the translation of the PKA catalytic subunit PKA-C.

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#Id: 3806

#Unit 5. Developmental Biology

A second glycoprotein secreted during starvation is CMF (conditioned medium factor)