TLS Online TPP Program

#Id: 7883

#Unit 2. Cellular Organization

MICOS function as a diffusion barrier to prevent mixing of the distinct proteins and lipids in the boundary membrane and crista membranes.

TLS Online TPP Program

#Id: 7884

#Unit 2. Cellular Organization

The most abundant protein in the outer mitochondrial membrane is a mitochondrial β-barrel porin called VDAC (voltage-dependent anion channel).

TLS Online TPP Program

#Id: 7885

#Unit 2. Cellular Organization

VDAC 

A multifunctional transmembrane channel protein (similar in structure to bacterial porins) allow passing of  ions and most small hydrophilic molecules (up to about 5000 Da).

TLS Online TPP Program

#Id: 7886

#Unit 2. Cellular Organization

Mitochondria are associated with the cytoskeleton, which determines their distribution in different cell types.

TLS Online TPP Program

#Id: 7887

#Unit 2. Cellular Organization

In highly polarized cells, mitochondria can move long distances being propelled along microtubule tracks

TLS Online TPP Program

#Id: 7888

#Unit 2. Cellular Organization

In other cells, mitochondria remain fixed at points of high energy demand.