Four stages of the evolutionary progression of cancer:

Initiation→Cancer progression → Evasion of cancer cell elimination  → Tumor growth and dispersal 

TLS Online TPP Program

#Id: 8917

#Unit 2. Cellular Organization

TLS Online TPP Program

#Id: 8918

#Unit 2. Cellular Organization

Centralspindlin is a heterotetramer composed of two copies of the kinesin-6 motor protein MKLP1 and a dimer of a Rho GAP

TLS Online TPP Program

#Id: 8919

#Unit 2. Cellular Organization

MKLP1 is inhibited by 14-3-3 to ensures that the spindle midzone microtubules do not compact until the end of anaphase

TLS Online TPP Program

#Id: 8920

#Unit 2. Cellular Organization

During anaphase, when cyclin B-CDK1 activity is extinguished but Aurora and Polo kinases are still active, Aurora B phosphorylates MKLP1 and displaces the 14-3-3, allowing compact the spindle midzone.

TLS Online TPP Program

#Id: 8921

#Unit 2. Cellular Organization

At the same time, Plk1 phosphorylates the Rho-GAP component, to form an active Centralspindlin-Ect2 complex. 

TLS Online TPP Program

#Id: 8922

#Unit 2. Cellular Organization

Centralspindlin-Ect2 complex catalyzes activation of RhoA, leading to cleavage furrow formation and division of the cytoplasm to form two completely separate cells.