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TLS Online TPP Program

#Id: 5270

The inherent leakiness of the sinus nodal fibers to sodium and calcium ions causes their self-excitation.

#Unit 7. System Physiology – Animal #Cardiovascular System #Part B Pointers
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TLS Online TPP Program

#Id: 1546

#Unit 2. Cellular Organization

Plectin links microtubules to intermediate filaments.
 
TLS Online TPP Program

#Id: 1547

#Unit 2. Cellular Organization

Taxol, 
A plant alkaloid from the Pacific yew tree
Binds microtubules and stabilizes them against depolymerization
TLS Online TPP Program

#Id: 1548

#Unit 2. Cellular Organization

Nocodazole and colchicine
TLS Online TPP Program

#Id: 1549

#Unit 2. Cellular Organization

Two main families of motor proteins mediate transport along microtubules:

Kinesins 

Dyneins
TLS Online TPP Program

#Id: 1550

#Unit 2. Cellular Organization

Kinesin-1 powers anterograde transport of vesicles down axons toward the (+) ends of microtubules.
TLS Online TPP Program

#Id: 1551

#Unit 2. Cellular Organization

Kinesin-1  (similar to myosin II)
Head domain at the N-terminus of the heavy chain  
Stalk domain forms a long coiled-coil
Tail domain at C-terminus that attaches to cargo