-         +         - -          +         - +          +        +           - 1          2         3           4                5         6 +          -         +           +                - +          -         +           +                -          -

TLS Online TPP Program

#Id: 10536

#Unit 4. Cell Communication and Cell Signaling

Neurotrophins binds with high affinity to the family of receptor tyrosine kinases called Trks-

NGF binds to TrkA

BDNF binds to TrkB

NT-3 binds to TrkC

TLS Online TPP Program

#Id: 10537

#Unit 4. Cell Communication and Cell Signaling

All neurotrophins also bind to a distinct type of receptor called p75NTR (NTR 5 neurotrophin receptor), but with lower affinity

TLS Online TPP Program

#Id: 10538

#Unit 4. Cell Communication and Cell Signaling

In healthy cells, the Bcl-2 or Bcl-xL blocking the ability of Bak or Bax to oligomerize and form pores in the outer mitochondrial membrane.

TLS Online TPP Program

#Id: 10539

#Unit 4. Cell Communication and Cell Signaling

Trophic factors (NGF) leads to activation of receptor tyrosine kinases (TrkA) and activation of the protein kinase B pathway

TLS Online TPP Program

#Id: 10540

#Unit 4. Cell Communication and Cell Signaling

PKB phosphorylates Bad, and phosphorylated Bad forms a complex with a cytosolic 14-3-3 protein.

TLS Online TPP Program

#Id: 10541

#Unit 4. Cell Communication and Cell Signaling

In the absence of trophic factors, nonphosphorylated

Bad binds to Bcl-2, releasing Bax and Bak and allowing them to form oligomeric membrane pores and holes.